Check out this page: http://linuxhcl.com/browse/product?id=6859

It mentions some libraries to install as well. Precise can use 32 and
64-bit, so you might want to try 32-bit versions after removing the 64-bit
ones. It can't hurt since it isn't working as is.

I had tried to install Iscan the other day, but I think
I got a corrupted data file. I tried again, and it installed, but now I have a
different problem. Simple Scan and Iscan now detect my V500 as an Epson
(unknown model) and the cannot talk to it. (The good news is that they work
with the network-connected Photosmart 2610 all-in-one.)

If I try to run xsane, it also sees the V500 as an unknown Epson, and it balks
over permissions for an epkowa emulator. Running xsane as root brings up a dire
warning, but the scanner is properly detected as an Epson V500, and it works!
I'm still researching the permissions issue.

If it runs when logged in a Root then you need to add the scanner
group to your user. That should allow it to run in normal mode :-)

Main thing is you managed to get it working :-)

E> I tried finding drivers on the Epson site, but it keeps pointing at
E> Iscan which I can't figure out how to install.

You do need to install Image Scan for Linux to get this working
correctly. Have you gone to this site and downloaded the .deb file ?
It should install by simply double clicking...

http://www.avasys.jp/lx-bin2/linux_e/scan/DL1.do