How are you trying to "know" the line  (row) and column?
When you make the change?
or afterward, look for the change?

Are you writing a script in VBA that you want to use to look for "s" in the
first column?

Are you wanting it to do something as soon as you make the change?

What is it that you are trying to do and how do you WANT it to work?

In VBA, using the Worksheet_SelectionChange event you can use
something like...

Cells(1,1) = Target.address